Viagra Vs Cialis

Viagra was the first to enter the pharmaceutical market in 1998, while Cialis only appeared in 2003.

The mechanism behind both drugs entails phosphodiesterase type 5 (PDE 5) enzyme blocking, which in turn decomposes cyclic guanosine monophosphate enzymes responsible for the vascular component of penis erection. However, a low level of cyclic guanosine monophosphate prohibits a full-grown erection among men with erectile dysfunction.

In order to raise the content of cyclic guanosine monophosphate to the level sufficient for erection required the application of a simple yet not very evident method: blocking the enzyme that decomposes cyclic guanosine monophosphate.

Pharmacokinetics data on Viagra vs Cialis testify to the greater effectiveness of the latter. Firstly, the effective half-life of sildenafil is shorter: only about 3 – 5 hours depending on the dose taken, while that of Tadalafil is 17.5 hours. Secondly, the effective functionality and erection achievement time frame for Viagra is only about 4 hours while the same for Cialis is between 24 and 36 hours.

As for possible side effects of Viagra vs Cialis, they are analogous: vertigo, headache, diarrhea, sickness, stuffy nose and hot flashes. Cialis is also known to produce rare pains in the back, stomach and joints.

All the undesired side effects of both drugs are passing and benign or moderate, as a rule. In the case of Cialis intake, side effects are known to substantially lessen as the drug is taken on a more regular basis.

Both drugs are prohibited for men constantly taking nitroglycerine drugs or their analogues.

While Viagra has been the leader in new generation drugs and has existed in the market for 15 years, some negative facts regarding it have come to light.

In 2002 the American toxicologist G. Millman published the results of his scientific research about the side effects of Viagra in “Annals of Pharmacotherapy” magazine. The patients taking Viagra mentioned vertigo, disorientation and amnesia; the appearance of aggression was registered among 22 men out of 270, 13 were registered with violent tendencies and 6 were reported to have a “stable desire to kill”. The side effects of sildenafil became apparent in the case of long-term ingestion of therapeutic doses (100 mg per day).

Other sources irrespective of each other reported on the incompatibility of Viagra with alcohol. The reciprocal exponentiation of Viagra’s hypotensive effects combined with alcohol cost many elderly their lives who didn’t comply with the prohibition of alcohol while using the drug.

Numerous clinical research works on the effectiveness and safety of Cialis underline the absence of restrictions in taking the drug with fat foods and alcohol in small (!) dozes, which considerably heightens the loyalty of patients and meets their daily life requirements.

Hereby, the analysis of existing scientific and clinical facts about the qualities and effect of Viagra vs Cialis suggest choosing the latter over the former. Furthermore, do not forget that these drugs do treat impotence but are not a panacea.

Some problems concerning the male genital zone are beyond the capabilities of medicinal therapy and demand other methods of non-medicinal treatment.