This combination gives the most effective death lowering, a regular issue of British Medical Journal reports; the adding of ACE inhibitor is reasonable only in case of attending cardiac decompensation. Dr. Julia Hippisley-Cox and Dr. Carol Coupland (Public Health School, Nottingham) have analyzed the data of 13029 patients with diagnosed CHD. 2266 of them died; 9064 of the survivors comparable by the age, sex, and the year of diagnosing the case were included into the control group.
It turned out that the combination of statins, aspirin, and beta blockers led to the maximum lowering of death rate (- 83 %). The addition of ACE inhibitors led to the decrease of risk 75 % down, the combination of statins, aspirin, and ACE inhibitors decreased the risk 71 % down. The effect of beta blocker monotherapy (- 19 %), ACE inhibitor monotherapy (20 %), and the combination of beta blockers and ACE inhibitors (- 31 %) was poorer.
In other article of the same issue Dr. Tom Faley (Dundee University), Dr. Peter Brindle, and Dr. Shah Ibrahim (Bristol University) write that the received data prove the polipyll concept: the repeated prevention of cardiovascular diseases requires combined therapy.
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